Investigation of central versus peripheral effects of estradiol in ovariectomized mice
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چکیده
منابع مشابه
Investigation of central versus peripheral effects of estradiol in ovariectomized mice.
It is generally believed that estrogens exert their bone sparing effects directly on the cells within the bone compartment. The aim of the present study was to investigate if central mechanisms might be involved in the bone sparing effect of estrogens. The dose-response of central (i.c.v) 17beta-estradiol (E2) administration was compared with that of peripheral (s.c.) administration in ovariect...
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Age-related loss of ovarian function promotes adiposity and insulin resistance in women. Estrogen (E(2)) directly enhances insulin sensitivity and suppresses lipogenesis in peripheral tissues. Recently, the central actions of E(2) in the regulation of energy homeostasis are becoming clearer; however, the functional relevance and degree of contribution of the central vs. peripheral actions of E(...
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Background & Aims: Adult neurogenesis occurs in the two main areas of the brain of most mammalian species in; sub ventricular zone, and the dentate gyrus of the hippocampus. Many factors such as 17-β estradiol affect neurogenesis in the hippocampus. The aim of this study was to investigate the effect of exogenous 17-β estradiol on neurogenesis in the ovariectomized (OVX) mice. Materials & Meth...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2005
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.1.06181